Flavin-dependent thymidylate synthase: a novel pathway towards thymine.

Flavin dependent thymidylate synthase as a new antibiotic target

In humans de novo synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP), an essential building block of DNA, utilizes an enzymatic pathway requiring thymidylate synthase (TSase) and dihydrofolate reductase (DHFR). The enzyme flavin-dependent thymidylate synthase (FDTS) represents an alternative enzymatic pathway to synthesize dTMP, which is not present in human cells. A number of pathogenic ba...

Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.

The inhibition of de novo thymidine (dThd) synthesis by the novel folate-based thymidylate synthase (TS) inhibitor ZD1694 (Tomudex) can achieve tumor cell-specific cytotoxicity in vivo. However, nucleosides in the surrounding microenvironment of tumors may be used by the salvage pathway to regenerate any depleted pools, thus providing an efficient mechanism through which to circumvent the ZD169...

Crystallization and preliminary crystallographic studies of a flavin-dependent thymidylate synthase from Helicobacter pylori.

The ThyX enzymes that have recently been identified in various bacteria, including some important human pathogens such as Helicobacter pylori and Mycobacterium tuberculosis, are flavin-dependent thymidylate synthases that function in the place of classic thymidylate synthase enzymes in the biosynthesis of dTMP, which is one of the building blocks of DNA. They are promising targets for the devel...

Mycoplasma Pyrimidine Deoxynucleotide Biosynthesis Molecular Characterization of a New Family Flavin-Dependent Thymidylate Synthase

Correction: Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine.

Correction for 'Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine' by Palwinder Singh et al., Chem. Commun., 2015, 51, 9961-9964.